The concomitant usage of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may well cause an increase in methadone plasma concentrations, which could result in perhaps deadly respiratory melancholy. In addition, discontinuation of concomitantly applied cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers can also cause a rise in m